Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk type of blood-cell cancer.We describe the improvement of a candidate therapeutic virus for virotherapy of leukemic cells.Virotherapy is based on the exclusive replication of a virus in leukemic cells, leading to the selective removal of these malignant cells.To improve the safety o
Genetic Alterations in Intervertebral Disc Disease
Background: Intervertebral disc degeneration (IVDD) is considered a multifactorial PANTIES disease.The last two decades of research strongly demonstrate that genetic factors contribute about 75% of the IVDD etiology.Recent total genome sequencing studies have shed light on the various single nucleotide polymorphisms (SNPs) that are associated with
Responses of the molluscan fauna to environmental variations in a Halodule wrightii Ascherson ecosystem from Northeastern Brazil
ABSTRACT This study observed the spatial and temporal distributions of molluscs in a Halodule wrightii meadow, verifying if they respond satisfactorily to seasonal changes in this seagrass ecosystem.Twenty-four species were identified.Chitons were rare, bivalves had greater number of species (11), followed by gastropods (9) which were also the most
Catchment-scale conservation units identified for the threatened Yarra pygmy perch (Nannoperca obscura) in highly modified river systems.
Habitat fragmentation caused by human activities alters metapopulation dynamics and decreases biological connectivity through reduced migration and gene flow, leading to lowered levels of population genetic diversity and to local extinctions.The threatened Yarra pygmy perch, Nannoperca obscura, is a poor disperser found in small, isolated populatio